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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPR1 All Species: 37.27
Human Site: T612 Identified Species: 74.55
UniProt: P16066 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16066 NP_000897.3 1061 118919 T612 P P N I C I L T E Y C P R G S
Chimpanzee Pan troglodytes XP_001168194 1047 116964 T596 P P N I C I V T E Y C P R G S
Rhesus Macaque Macaca mulatta XP_001085221 1047 116990 T596 P P N I C I V T E Y C P R G S
Dog Lupus familis XP_547577 1060 118154 T611 P P N I C I L T E Y C P R G S
Cat Felis silvestris
Mouse Mus musculus P18293 1057 119091 T608 P P N I C I L T E Y C P R G S
Rat Rattus norvegicus P18910 1057 118933 T608 P P N I C I L T E Y C P R G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517544 743 84256 S340 S I I G H H G S L K S S N C V
Chicken Gallus gallus
Frog Xenopus laevis NP_001083703 1056 120483 T606 P P N I C I L T E Y C P R G S
Zebra Danio Brachydanio rerio NP_001038402 1067 121798 T618 P P N I C I L T E Y C P R G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 T604 H G S V I I F T T Y C A R G S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 T636 S A H F I S V T K L C S R G S
Sea Urchin Strong. purpuratus P16065 1125 126238 M645 R P H I S I L M H Y C A K G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 61.2 61.2 91.6 N.A. 90.8 90.8 N.A. 48.5 N.A. 66.1 62.7 N.A. 31.5 N.A. 29.8 35.1
Protein Similarity: 100 73.8 73.8 95 N.A. 94.2 94.2 N.A. 58.6 N.A. 78.7 77.5 N.A. 47.8 N.A. 49 50.8
P-Site Identity: 100 93.3 93.3 100 N.A. 100 100 N.A. 0 N.A. 100 100 N.A. 46.6 N.A. 33.3 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 N.A. 100 100 N.A. 60 N.A. 53.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 0 0 0 0 0 17 0 0 0 % A
% Cys: 0 0 0 0 67 0 0 0 0 0 92 0 0 9 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 9 0 0 9 0 0 0 0 0 0 92 0 % G
% His: 9 0 17 0 9 9 0 0 9 0 0 0 0 0 0 % H
% Ile: 0 9 9 75 17 84 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 9 9 0 0 9 0 0 % K
% Leu: 0 0 0 0 0 0 59 0 9 9 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 67 0 0 0 0 0 0 0 0 0 9 0 0 % N
% Pro: 67 75 0 0 0 0 0 0 0 0 0 67 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 0 0 0 0 0 0 84 0 0 % R
% Ser: 17 0 9 0 9 9 0 9 0 0 9 17 0 0 92 % S
% Thr: 0 0 0 0 0 0 0 84 9 0 0 0 0 0 0 % T
% Val: 0 0 0 9 0 0 25 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 84 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _